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Cardiac remodeling after MI is caused
2020-08-05
Cardiac remodeling after MI is caused by activated myofibroblasts. They are attracted to the infarct region by various chemotactic factors, including TGF-β1, which is mainly produced by fibroblasts. TGF-β1 promotes trans-differentiation from fibroblasts to myofibroblasts, and upregulates biosynthesi
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Approximately of the etamicastat dose was recovered
2020-08-05
Approximately 50% of the etamicastat dose was recovered in urine, 30% in the form of etamicastat and 20% in the form of BIA 5-961. These data agree with those from a study with [14C]-labeled etamicastat in healthy subjects, which showed that approximately 95% of the administered radioactivity had b
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Another novel finding of our study was
2020-08-05
Another novel finding of our study was that the global 5 hmC was down-regulated and was associated with a substantial reduction of TET expression in the PE placentas compared with the controls. The decreased global 5 hmC level was consistent with the increased global 5 mC level in the preeclamptic p
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Findings from previous register based studies favor ours as
2020-08-05
Findings from previous register based studies favor ours as use of Kaempferol alone or in combination with progestogen among≥75year old women was not beneficial for cognitive performance [28]. Medical records based use of oral or parenteral estrogen use for ≥6 months among 264 AD cases and 264 cont
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A number of studies have been carried
2020-08-04
A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key Angiotensin 1/2 (1-7) amide of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, A
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Moreover recent structural studies of VEEV nsP pro in comple
2020-08-04
Moreover, recent structural studies of VEEV nsP2pro in complex with E-64d revealed an important molecular interaction at the interface of two subdomains. In this structure, Asn475 which is in polar contact with carbonyl oxygen of Asp507 of the protease subdomain makes an H-bond with Arg662 of the MT
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Paraffin embedded tissue blocks were transferred from the
2020-08-04
Paraffin embedded tissue blocks were transferred from the University of Florence, Florence, Italy, to the Department of Cellular Pathology at the Royal Free Hospital, London, UK, where the study was performed. Each tissue block was processed according to the reported CPA method and analysed for coll
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Melatonin In the particular case of metals several
2020-08-04
In the particular case of metals, several authors showed that AChE inhibition is somewhat contradictory and even questionable (Frasco et al., 2005, Nunes et al., 2005, Sáenz et al., 2010). Uranium is a particular metal, and one that has been shown to complex with several biologically important prote
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br Funding This study was
2020-08-04
Funding This study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), and Fundação de Apoio à Equipe e à Inovação Tecnológica do Estado
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With these results it is now important
2020-08-04
With these results, it is now important to predict whether a similar response could be obtained in humans immunized with the same E1 sequences. Thus, we used the same analysis criteria to predict peptides for HLA-A2, which is the largest and most diverse allele family in humans [47]. This revealed t
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Total synthesis requires the two key intermediates
2020-08-04
Total synthesis requires the two key intermediates 3 and 7, which were synthesized using the route described in below. Phenylethylamine 3 was readily synthesized from vanillin or isovanillin; the overall yield was 50–52%. To prepare the intermediates 7, bromination of 2-(4-hydroxyphenyl) acetate wi
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Traditionally serum triglycerides have been measured in the
2020-08-04
Traditionally, serum triglycerides have been measured in the clinic in the fasted state in order to reduce variability and also to facilitate the calculation of LDL-cholesterol via the Friedewald equation, which was derived using fasted samples (Warnick and Nakajima, 2008). We have previously report
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DNA methylation is an important mechanism
2020-08-03
DNA methylation is an important mechanism regulating gene expression, and it is required for normal mammalian development.26, 27, 28 Alteration in DNA methylation is a hallmark of cancer10, 29, 30 and may be observed as a loss of global methylation or as a gain of methylation of selected CpG islands
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DC260126 Introduction Hepatocarcinoma is a common and
2020-08-03
Introduction Hepatocarcinoma is a common and aggressive form of cancer (Trad et al., 2017). Due to a high rate of postoperative recurrence and metastasis, the prognosis for HCC remains dismal (Wang et al., 2017a, 2017b). Subclinical metastasis is the major cause responsible for tumor recurrence and
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Ubiquitination is a highly conserved process in eukaryotic o
2020-08-03
Ubiquitination is a highly conserved process in eukaryotic organisms, which depends on the sequential activity of three different enzymes: an ubiquitin-activating enzyme (E1), an ubiquitin-conjugating enzyme (E2) and an ubiquitin ligase (E3). E1s use ATP to bind a molecule of ubiquitin to the Cys re
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