• br CDKs as Direct Coactivators of Proinflammatory

  2021-03-03

  

  CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1. This is achieved at two levels because CDKs can affect gene expression by targeting global transcription

• Other mutations in the SYNE region exons

  2021-03-03

  

  Other mutations in the SYNE1 3′ region (exons 81–85) have been implicated in an upper motor neuron disease, ARCA1 (Gros-Louis et al., 2007). The disease is characterized by progressive movement, coordination, and balance problems caused by disrupted Purkinje cell function and their impaired signalin

• Cerdulatinib From the results of previous experiments

  2021-03-02

  

  From the results of previous experiments with the purvalanol B affinity matrix, it is not clear whether the selective capture of parasite CK1 enzymes is a reflection of their high abundance or rather their affinity for the ligand compared with other kinases present in the lysates. Based on compariso

• br Acknowledgements This work was supported by a grant from

  2021-03-02

  

  Acknowledgements This work was supported by a grant from the Deutsche Forschungsgemeinschaft to Uwe Knippschild and Martin Wabitsch (SFB 1149/B4). P. Fischer-Posovszky is funded by a Margarete von Wrangell scholarship financed by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württem

• br Materials and methods br Results br Discussion

  2021-03-02

  

  Materials and methods Results Discussion Schistosome cercarial elastase secreted from the acetabular glands of cercariae is recognized to play a critical role in mammalian host skin penetration upon infection. The present study extends the understanding of biochemical and immunological prop

• Introduction Proteins play an important

  2021-03-02

  

  Introduction Proteins play an important role in cellular functions; however, being and remaining properly folded is necessary for their function. Understanding the stability of the protein is necessary to investigate the folding of proteins, as well as their conformation, functions and interactions

• oxidative phosphorylation The cytoplasmic domain of classica

  2021-03-02

  

  The cytoplasmic domain of classical cadherins is highly conserved and can interact with different cytosolic proteins. Typically this domain is associated with catenin family members, including p120 catenin, β-catenin, and α-catenin, which form a cadherin-catenin complex (Fig. 1). The catenin family

• br Restenosis after angioplasty remains a remarkable

  2021-03-02

  

  Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle Famprofazone (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrate

• br Materials and methods br

  2021-03-02

  

  Materials and methods Results Discussion Drug of abuse induces widespread Concanamycin A changes in the molecular and cellular functions in circuits between VTA and its neighbored regions such as NAC, and amygdala. It is belived that these changes result behavioral phenotype that character

• Collectively the results presented here provide new insights

  2021-03-02

  

  Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of

• RNA sequencing RNA seq is a particularly

  2021-03-02

  

  RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (D

• The mechanisms in the central nervous system CNS controlling

  2021-03-02

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the DPQ are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by enhancement of NA turno

• Mild cognitive impairment MCI is a clinical transitional sta

  2021-03-02

  

  Mild cognitive impairment (MCI) is a clinical transitional stage between normal aging and Alzheimer disease (AD) [1]. Approximate 15–30% MCI patients convert to AD annually. Although many efforts have been taken to prevent the conversion from MCI to AD [2], [3], there are few biomarkers to predict t

• br Methods br Results br Discussion Literature

  2021-03-02

  

  Methods Results Discussion Literature showed SN was well studied for its antigastric ulcer, antiinflammatory, antihyperglycemic, and antihyperlipidemic properties. Although a recent publication reported that SN was found to exert its regulatory effect in animal cholesterol levels, the exact

• The mitogen activated protein kinase

  2021-03-02

  

  The mitogen-activated protein kinase (MAPK) pathway is a highly conserved module that mediates the transduction of signals from the cell surface to the nucleus (M. Köbel et al., 2005), meanwhile, it is known to be activated by a wide array of signals ranging from growth and differentiation factors t

16319 records 730/1088 page Previous Next First page 上5页 726727728729730 下5页 Last page