• Several transgenic and knockout congenic mouse

  2021-11-08

  

  Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig

• br Methods and materials br Results br Discussion In

  2021-11-08

  

  Methods and materials Results Discussion In this study we demonstrate that CF epithelial Spermine NONOate exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible

• Combination inhibitors of FAAH TRPV and or COX

  2021-11-08

  

  Combination inhibitors of FAAH, TRPV1, and/or COX2 may have the advantage of effective pain relief with a high therapeutic index. For example, arachidonoyl serotonin (AA-5-HT) inhibits both FAAH (IC=1–12μM) and TRPV1 (IC=37–270nM against 100nM capsaicin in HEK-293 cells)., In mice, AA-5-HT had grea

• We have expanded these studies by doing

  2021-11-08

  

  We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA N6-Cyclopentyladenosine or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA recep

• The most abundant form of Hat p

  2021-11-08

  

  The most abundant form of Hat1p in the nucleus is apt to be in the form of the NuB4 complex [96]. In the context of (±)-J 113397 assembly, the function of the NuB4 complex may be similar to that ascribed for the cytoplasmic HAT1 complex. That is, the NuB4 complex may be involved in directing newly s

• CMX001 One class of microbial derived

  2021-11-08

  

  One class of microbial-derived metabolites that have received significant attention are the short-chain fatty acids (SCFA), which include butyrate, acetate and propionate. The production of SCFA occurs in the colon following microbial fermentation of dietary fibers and SCFA can also be consumed in c

• In addition recent research shows that HK contributes to the

  2021-11-08

  

  In addition, recent research shows that HK2 contributes to the inhibition of apoptosis through the suppression of the formation of mitochondrial permeability transition pores in association with voltage-dependent anion channel (VDAC) protein [11]. We also found that AKT2 mediates HK2 resistance to a

• br Heme oxygenase inhibitors Historically the first class of

  2021-11-08

  

  Heme oxygenase-1 inhibitors Historically, the first class of competitive HO-1 inhibitors was represented by MPs, heme analogs in which the central iron DLPC of heme is exchanged by another element, such as zinc, cobalt, tin, or chromium. These molecules compete with heme for binding to the enzyme

• In addition to changes in the

  2021-11-06

  

  In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer BAY 57-1293 (Chan et al., 20

• For some agonists these stable GPR

  2021-11-06

  

  For some agonists, these stable GPR119 responses were resistant to washing. Thus, sustained activation could continue, for at least a number of hours, even after removal of free agonist. These data are consistent with reports for other GPCR systems that do not desensitize (Calebiro et al., 2009, Fer

• Our inhibitor studies revealed the presence of a

  2021-11-06

  

  Our inhibitor studies revealed the presence of a signaling network triggered by dicarbonyl stress. Nevertheless, p38-MAPK activation was clearly necessary for NADPH-oxidase mediated production of ROS. This is consistent with data from other groups using different cell culture systems [37], [38], [39

• The glycine receptor is an ionotropic neurotransmitter

  2021-11-06

  

  The glycine receptor is an ionotropic neurotransmitter receptor coupled to a chloride ion channel. Glycine receptors are typically described as inhibitory and distributed in the spinal cord and brainstem, though mRNA transcription labelling studies in rats show expression in the hippocampus, cingula

• To maintain low Glu concentrations in the synaptic cleft

  2021-11-06

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino Diclofenac australia is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocyt

• In the spinal cord EAAT constitutes of

  2021-11-06

  

  In the spinal cord, EAAT1 constitutes 40% of all high-affinity EAATs, and it is abundantly present in lumbar dorsal horn (Queen et al., 2007). In physiological conditions, EAATs remove glutamate from the synaptic cleft by co-transporting glutamate and sodium into adjacent glial cells. The inefficien

• Animal studies have shown that various antidepressant treatm

  2021-11-06

  

  Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key phorbol myristate acetate regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulat

16322 records 583/1089 page Previous Next First page 上5页 581582583584585 下5页 Last page