• br Mechanisms for regulation of intracellular cholesterol

  2024-09-05

  

  Mechanisms for regulation of intracellular cholesterol homeostasis Cells maintain intracellular free cholesterol levels and distribution within stringent tolerances by several mechanisms [55]: (1) uptake of native LDL (the major extracellular carrier of cholesterol) by LDL receptors and modified

• PL for actin in vitro showed that

  2024-09-04

  

  PL for thymidine phosphorylase inhibitor in vitro showed that its profiles, including particular peak and intensity, could determine the length and thickness of an actin filament. Furthermore, we investigated if the PL intensity peak at approximately 340 nm can also be originated from another cytosk

• br Roles for GMF in Endocytic Traffic

  2024-09-04

  

  Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune WIKI4 42, 51. Vinculin, a central component of focal adhesions that anchors cells to th

• It is interesting that Li et al reported

  2024-09-04

  

  It is interesting that Li et al. (2008) reported that AChR-immunized FcγRIIB knock out (KO) mice are significantly resistant to antibody-mediated EAMG. This is in contrast with previous studies, but does not contradict the results presented here. Despite their observation that the incidence and seve

• Using constant potential amperometry and electrochemical enz

  2024-09-04

  

  Using constant potential amperometry and electrochemical enzyme-based biosensors selective for choline—and, therefore, an accurate readout of Golgicide A synthesis release (Baker et al., 2015; Bruno et al., 2006a; Parikh et al., 2004, 2007)—tonic and phasic release of acetylcholine were measured si

• Our data indicate that the D domain only needs

  2024-09-04

  

  Our data indicate that the D1 domain only needs to hydrolyze ATP a few times, or perhaps even just once, during the processing of a given substrate molecule, whereas the D2 domain hydrolyzes ATP many times. Consistent with this model, only D2 contains the canonical aromatic pore loop residues implic

• Introduction An association of elevated branched

  2024-09-04

  

  Introduction An association of elevated branched-chain (-)-MK 801 (BCAA—Leu, Val, Ile) with obesity and insulin resistance was first reported nearly 50 years ago (Felig et al., 1969). With the advent of metabolomics technologies, it has since become apparent that the association of BCAA and related

• The skin permeability barrier is important for the

  2024-09-04

  

  The skin permeability barrier is important for the prevention of loss of water and electrolytes from inside the body and for protection against the invasion of external pathogens, allergens, and harmful compounds. Multi-layered lipids, called lipid lamellae, are present in the outermost cell layer o

• There is little question that as we become more

  2024-09-04

  

  There is little question that as we become more proficient in the diagnosis of arginase 1 deficiency individuals with intermediary elevations in arginine on newborn screening and partial defects in enzymatic activity will be found. There are no reliable data to determine a safe level of arginine and

• The isoelectric point of CL ARG

  2024-09-04

  

  The isoelectric point of CL-ARG was determined by native IEF at a SR 11302 gradient in the range (3–10) using standard protein markers with known isoelectric points. Native IEF reveals the presence of only one major band for CL-ARG with a slightly neutral-basic pI value of about 7.7. The calculated

• br Results br Discussion Control of chronic inflammation

  2024-09-04

  

  Results Discussion Control of chronic inflammation is important in several inflammatory conditions like asthma, rheumatoid arthritis and fibrosis in lung diseases. The regulatory pathways that control chronic inflammation are complex and multi-factorial. Over expression of inflammatory mediato

• Protein microarrays represent just one of a variety of exper

  2024-09-04

  

  Protein microarrays represent just one of a variety of experimental approaches that can be used to generate datasets of relevance to pathway mapping. Other approaches include protein SB 431542 profiling techniques, such as antibody arrays [29], tissue arrays [30] and 2-dimensional gel electrophoresi

• br Conclusion br References and recommended

  2024-09-04

  

  Conclusion References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Nucleosome, the basic chromatin unit, is composed of DNA and core histones (H2A, H2B, H3 and H4) and organized into

• br Results and discussion This paper reports the synthesis o

  2024-09-04

  

  Results and discussion This paper reports the synthesis of methoxy and 4-thio derivatives of quercetin and luteolin, which includes two new derivatives (4 and 12) and explores how subtle variations in the chemical structure of flavonoids affect their biological activity, particularly in relation

• Ac-IETD-AFC In the present study a splice acceptor

  2024-09-04

  

  In the present study, a splice acceptor site mutation (c.1769-1G > C) was identified in AR gene from patients with CAIS. The c.1769-1G > C mutation results in replacement of the normal sequence (CAG/G) with a new sequence (CAC/G) at the splice acceptor site of intron 2. In the splice acceptor site r

15813 records 56/1055 page Previous Next First page 上5页 5657585960 下5页 Last page