• Ironically another series of studies examining the role of

  2022-03-03

  

  Ironically, another series of studies examining the role of EAATs in CNS injury and disease suggest that under some pathological conditions, the operation of the EAATs is not protective, but actually contributes to the excitotoxic process (Rossi et al., 2000). The transporters do so by serving as th

• Introduction l Glutamate is a major excitatory neurotransmit

  2022-03-03

  

  Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is

• In this study for the

  2022-03-03

  

  In this study, for the first time: 1) the electrochemical glutamate oxidase-based biosensor was optimized for the determination of low micromolar glutamate concentrations; 2) the algorithm of the analysis of exocytotic and transporter–mediated glutamate release was developed; 3) the comparative anal

• Herein in consider of the high similarity between GR HBP

  2022-03-02

  

  Herein, in consider of the high similarity between GR HBP site and AR HBP site, we applied rational drug design strategy to develop AR/GR antagonists based on the chemical structures of antiandrogens and crystal structure of GR. The following bioassay identified Z19 as a dual AR/GR antagonist. Z19 i

• br Conclusions We have shown that despite the

  2022-03-02

  

  Conclusions We have shown that despite the development of severe insulin intolerance and marked alterations in whole body substrate oxidation that Gcgr−/− mice are protected against olanzapine-induced hyperglycemia. Our data provides evidence that this protective effect is likely due in large par

• BAY-6076 The SNPs of candidate genes may exert their effect

  2022-03-02

  

  The SNPs of candidate genes may exert their effect on associated traits through changing of gene expression (Bonafe et al., 2003, Wyszynska-Koko et al., 2006). In agreement, GHSR SNPs were significantly associated with upregulation of this gene in the pituitary gland of GG/GG chickens. The GHRL/GHSR

• The effect of GC on Fgf was

  2022-03-02

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 lumiracoxib was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secretion [28]

• Encouraged by the observation obtained from region A

  2022-03-02

  

  Encouraged by the observation obtained from region A, we selected the structure of 1 as the next template to successively pursue the SAR on regions B-D of 1 (lower side of Fig. 2). Next, we turned attention to the external aromatic ring of 1 to verify the impact on the antagonistic activity and prep

• While there have been a variety

  2022-03-02

  

  While there have been a variety of recent reviews on the signaling and physiological effects of FFA4, particularly towards its anti-inflammatory effects, the goal of this research update is to present the most recent details on the role of FFA4 in human cancers. The known contributions of FFA4 towar

• br Mechanisms of Resistance As

  2022-03-02

  

  Mechanisms of Resistance As with other cancer treatments in development, resistance is a concern with HHIs. Most observations regarding HHI resistance originate from patients with BCC [78]. In the clinic, resistance to vismodegib and sonidegib were observed when used to treat advanced BCC [78], [

• Apo E is defined as a polym http

  2022-03-01

  

  Apo E is defined as a polymorphic protein arising from three alleles. The human Apo E gene was widely studied and described to be located on chromosome 19, closely linked to the Apo C-I/C-II gene complex [9]. The three major alleles, termed Epsilon-2, Epsilon-3 and Epsilon-4 have been reported [10].

• FSLLRY-NH2 mg br Materials and methods br Results

  2022-03-01

  

  Materials and methods Results Discussion In this study, the supF forward mutation assay showed that 5OHU induced mutations in human cells and that a C→T mutation was the predominant mutation among 5OHU-induced mutations. In addition, the DNA cleavage activity assay revealed that 5OHU was ex

• br WM astrocytes Grey matter

  2022-02-28

  

  WM astrocytes Grey matter astrocytes express a variety of GluR types that have both physiological and pathophysiological significance [87]. Non-NMDA GluR are also expressed in WM astrocytes [40], although the functionality of these receptors has not been tested. The fibrous astrocytes that popula

• The OTR and GHSR are known to play similar

  2022-02-28

  

  The OTR and GHSR are known to play similar roles in centrally regulated behaviours, where the OTR is implicated in mood, sociability and appetite regulation (Morton et al., 2012; Myers et al., 2014; Sala et al., 2013; Lukas et al., 2011; Slattery and Neumann, 2010), with the GHSR primarily involved

• Our own search towards aryl imidazole derived GSMs led to

  2022-02-28

  

  Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,

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